Rx Vetoryl (trilostane) Capsules for Dogs

Rx Vetoryl (trilostane) Capsules for Dogs

Vetoryl (trilostane) Capsules are used for the treatment of hyperadrenocorticism (Cushing's syndrome or disease) in dogs. This includes both pituitary-dependent and adrenal-dependent forms of the disease. Vetoryl is an adrenocortical suppressant and is FDA-approved for oral use in dogs only.

Directions:

Always provide the Client Information Sheet with the prescription.

The starting dose is 1.0-3.0 mg/lb (2.2-6.7 mg/kg) once daily, administered with food. Capsule combinations may be required depending on the dog’s weight.

Starting Dose Guidelines:

• 10–22 lb (4.5–10 kg): 30 mg once daily
• 22–44 lb (10–20 kg): 60 mg once daily
• 44–88 lb (20–40 kg): 120 mg (2 x 60 mg) once daily
• 88–132 lb (40–60 kg): 180 mg (3 x 60 mg) once daily
• Over 132 lb (60+ kg): Use appropriate capsule combinations

After 10–14 days of treatment, re-examine the dog and perform a 4–6 hour post-dosing ACTH stimulation test to determine further action.

Post-ACTH Cortisol Levels:

• <1.45 µg/dL: Stop treatment and restart at a lower dose
• 1.45–5.4 µg/dL: Continue current dose
• 5.4–9.1 µg/dL: Continue if signs are controlled, or increase dose if needed
• >9.1 µg/dL: Increase dose

Monitor closely after any dose change. If signs are not controlled throughout the day, split the daily dose into two and administer 12 hours apart. Long-term monitoring should occur at 30 days, 90 days, and every 3 months thereafter, including ACTH tests, physical exams, and bloodwork.

Cautions:

Do not use in dogs that are pregnant or have kidney or liver disease. Inform your veterinarian of all medications your dog is taking, including over-the-counter products.

In the case of overdose, symptomatic treatment for hypoadrenocorticism (e.g., corticosteroids, fluids) may be required.

Drug Interactions: Use ACE inhibitors with caution due to additive effects on aldosterone levels. Do not use potassium-sparing diuretics (e.g., spironolactone) with Vetoryl, as both may increase the risk of hyperkalemia.

 

This product requires a Valid prescription.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.